Neurogenic pain, often referred to as neuropathic pain, arises from damage or dysfunction in the nervous system. It can manifest as a sharp, burning, or tingling sensation and is commonly associated with conditions like diabetes (diabetic neuropathy), postherpetic neuralgia following shingles, and nerve damage from injuries or surgery. Managing neurogenic pain can be challenging, as it often does not respond well to standard pain relief medications.

A Neurogenic Topical Gel is designed to alleviate pain by applying medication directly to the affected area, offering targeted relief with minimal systemic side effects. These gels can be particularly effective for localized symptoms of neurogenic pain, providing a direct anti-inflammatory, analgesic, or anesthetic effect.

WHAT IS LOW DOSE LDN USED TO TREAT?

• Autoimmune Diseases: Including multiple sclerosis (MS), rheumatoid arthritis, Crohn’s disease, and lupus, where LDN is thought to modulate the immune system and reduce inflammation.​
• Chronic Pain Disorders: Such as fibromyalgia and chronic regional pain syndrome (CRPS), where LDN may help reduce pain sensitivity.​
• Inflammatory Skin Conditions: Like eczema and psoriasis, where LDN can help manage inflammation and autoimmune responses affecting the skin.​
• Thyroid Disorders: Particularly Hashimoto’s thyroiditis, an autoimmune condition affecting the thyroid gland, where LDN can help regulate immune function.​
• Cancer: Some preliminary studies suggest that LDN could play a role in cancer treatment by boosting the immune response, though more research is necessary.

WHAT IS THE ACTIVE INGREDIENT?

The active ingredients in these neurogenic pain gels can vary widely, depending on the patient’s specific needs and the underlying cause of the neurogenic pain. Common active ingredients may include:

• Local Anesthetics: Such as lidocaine or prilocaine, which numb the area and provide immediate pain relief.​
• Anti-Inflammatories: Including NSAIDs like diclofenac or ketoprofen, which reduce inflammation and pain.​
• Anticonvulsants: Gabapentin and pregabalin can be formulated for topical use and are often used in treating neuropathic pain.​
• Capsaicin: Derived from chili peppers, it can decrease the intensity of pain signals when applied topically.​
• Amitriptyline or Other Tricyclic Antidepressants: Sometimes used topically, these can modulate pain pathways and are beneficial in neuropathic pain treatment.​
• Clonidine: It’s known for its analgesic properties, particularly in neuropathic pain, by acting on alpha-2 adrenergic receptors.